You’re staring at two boxes on the pharmacy shelf-same ingredient (crotamiton 10%), different forms (cream vs lotion). One spreads faster. One clings longer. Pick right, and you’ll get cleaner coverage and better comfort. Pick wrong, and you’ll fight residue, missed patches, or a flare of itch. This guide gives you a clear, practical way to choose, apply, and stay safe.
- TL;DR: Both forms contain 10% crotamiton. Cream is thicker and better for very dry skin and night use; lotion spreads faster on large or hairy areas and is easier for daytime.
- For scabies, coverage is king. Lotion helps speed and reach; cream helps staying power. Many guidelines still favor permethrin or ivermectin first.
- For plain itch (non-scabies), choose the base your skin tolerates: cream for dry, lotion for oily or sensitive.
- Safety: Avoid eyes, mouth, open skin. Not routinely used in infants; ask a clinician for kids, pregnancy, and breastfeeding.
- If symptoms don’t improve in a week (itch) or 14 days (scabies), or worsen, talk to a clinician.
Deciding Between Crotamiton Cream and Lotion
Same drug, different base. That base changes how it spreads, sticks, and feels. Your pick should match your skin type, the body area, and your goal (itch relief vs scabies eradication).
Quick rule of thumb: choose cream for dry, cracked zones that need staying power (shins, ankles, hands). Choose lotion when you need fast, even coverage over large or hairy areas (chest, back, thighs) or you want a lighter feel under clothes.
| Feature | Crotamiton Cream 10% | Crotamiton Lotion 10% |
|---|---|---|
| Texture | Thicker, more occlusive | Light, fluid, less greasy |
| Best for skin type | Dry, rough, scaly | Normal to oily, sensitive |
| Best for body areas | Hands, feet, shins, localized patches | Chest, back, thighs, hairy areas |
| Ease of spread (full-body) | Moderate-more effort to spread | High-quick, even coverage |
| Staying power | Higher-less rub-off | Lower-may need mindful application |
| Residue under clothes | More noticeable | Less noticeable |
| Sting on inflamed skin | Can be more noticeable | Usually milder |
| Speed for scabies coverage | Slower | Faster |
Best for / not for:
- Cream-Best for: dry, cracked zones; overnight use; winter skin. Not for: hot climates if residue bothers you; very hairy areas.
- Lotion-Best for: large-surface or hairy coverage; daytime use; warm weather. Not for: very dry, fissured skin that needs occlusion.
Quick decision cheat sheet:
- If you’re treating scabies on a very hairy chest/back or need to cover fast: pick lotion.
- If your hands or shins are desert-dry and itchy: pick cream.
- If you need to dress right after application: pick lotion.
- If itch wakes you at night and nothing “stays”: pick cream.
One more tip: some brands add fragrances or solvents that can irritate. If you have sensitive skin or eczema, scan the inactive ingredients for fragrance, propylene glycol, lanolin, or parabens. Choose the simpler formula.
What Crotamiton Does (and Doesn’t) Treat
What it does: Crotamiton is an antipruritic (itch reliever) that also has scabicidal activity (kills scabies mites) on the skin surface. Both cream and lotion are typically 10%.
Where it shines:
- General itch (e.g., insect bites, simple dermatitis) when you want a non-steroid option.
- As a scabies option when first-line treatments aren’t available or tolerated.
Where guidance is nuanced:
- Scabies: Many public health guidelines list permethrin 5% cream or oral ivermectin as preferred first-line options due to higher cure rates. Crotamiton can be used when those aren’t suitable or accessible.
- Children: In some regions, crotamiton is not recommended for young children; always ask a pediatric clinician.
Authoritative sources (by name):
- FDA labeling (Eurax crotamiton 10%): includes directions for scabies and pruritus; avoid eyes/mucosa; external use only. Label revisions have emphasized careful application and repeat dosing schedules.
- CDC Scabies Treatment Guidance (2024): highlights permethrin 5% cream and oral ivermectin as preferred; notes variable effectiveness of crotamiton and limited pediatric approval in the U.S.
- WHO Scabies Guidelines (2023): prioritize permethrin and ivermectin; allow crotamiton when first-line agents are unavailable/unsuitable.
- British National Formulary (2025): crotamiton is widely used as an antipruritic; scabies management typically favors permethrin in the UK.
Bottom line on efficacy: For itch without scabies, pick based on skin feel (cream vs lotion). For scabies, the form you choose affects coverage and comfort, but both contain the same drug. If you have access to permethrin or ivermectin and can use them safely, those are often the better bet; if not, crotamiton remains a practical option.
SEO note for clarity: people often search for crotamiton cream vs lotion when they’re deciding how to cover large areas quickly without leaving a greasy feel.
How to Apply Safely and Effectively
Use these steps to reduce missed spots and avoid irritation. The specifics differ whether you’re treating scabies or just itch.
For scabies (adults):
- Prep first: Cut nails short and clean under them. Take a cool shower and dry completely.
- Cool the skin: Wait 10-15 minutes after a hot shower so skin is not flushed (reduces stinging).
- Apply from neck down: Massage a thin film to every inch-between fingers/toes, under nails, wrists, armpits, belly button, groin folds, buttocks, behind knees, soles. Get help for back if needed.
- Amount: Full-body adult coverage usually needs 30-60 g per application (roughly 1-2 ounces), depending on body size and form (lotion spreads further).
- Hands: After each handwash, reapply to hands and wrists.
- Clothes and bedding: After application, wear clean clothes. Keep on for the directed time. Many labels advise repeating in 24 hours and bathing 48 hours after the last application; some clinicians use once daily for 2-5 days. Follow your local label or clinician’s plan.
- Household control: The same day you start, wash clothes, bedding, and towels used in the last 3 days in hot water and hot dry cycle. Seal non-washables in a bag for 72 hours.
- Contacts: Close contacts should be treated simultaneously per local guidance to avoid ping-pong reinfection.
For itch (non-scabies):
- Identify triggers: Sweat, heat, wool, fragrance-reduce what you can.
- Spot test: Try a small area first if you have sensitive skin.
- Apply thinly 2-3 times daily to itchy areas as needed. Avoid broken skin.
- Layer smart: If you also use moisturizer, apply crotamiton first to clean, dry skin; let it absorb 10-15 minutes; then moisturize. If using a prescribed steroid, follow your clinician’s sequence.
Common mistakes to avoid:
- Missing creases and under nails-classic reason treatments fail.
- Washing off early-reduces contact time.
- Applying to open wounds-risks burning and absorption issues.
- Heavy fragrance products on top-can irritate already inflamed skin.
Storage and handling:
- Room temperature, cap tight, away from heat and flame.
- Keep out of reach of children and pets.
Real-World Scenarios and Trade-Offs
Picking cream vs lotion often comes down to where you’ll use it and what your skin tolerates. Here are real scenarios to make the call easier.
- Very dry winter skin with itch: Cream wins. It stays put on rough patches like shins and hands and won’t vanish under sweaters.
- Full-body scabies coverage on a hairy chest/back: Lotion wins. It spreads faster and clings less to hair, which helps you avoid missed gaps.
- Office day right after application: Lotion. It feels lighter under clothes and dries faster.
- Nighttime itch that wakes you: Cream. The thicker base gives longer wear time.
- Hot, humid climate: Lotion. Cream may feel greasy and trap heat.
- Eczema-prone, reactive skin: Start with lotion if you’re sensitive to occlusive textures. If it stings, switch forms or pause and ask a clinician.
- Caregiver treating two adults in one evening: Lotion in a pump bottle saves time and helps even dosing. Keep a small cream tube for stubborn dry zones.
- Travel kit: Lotion if you need one product for both spot itch and potential wider coverage. Cream if your main issue is dry, cracked hands.
Decision tree (simple):
- Need to cover large or hairy areas fast? → Lotion.
- Need staying power on dry, rough patches? → Cream.
- Hate residue under clothes? → Lotion.
- Night use with persistent itch? → Cream.
Cost and availability note: Prices vary by region and brand. If you’re on a budget and need lots of product, lotion formats often come in larger sizes and may cover more surface per ounce.
Safety, Side Effects, and FAQs
Safety basics:
- External use only. Keep away from eyes, mouth, and mucous membranes. If contact happens, rinse well with water.
- Do not use on open, weeping, or acutely inflamed skin unless a clinician says it’s okay.
- Stop and seek advice if you get a rash, severe burning, swelling, or hives.
- Children, pregnancy, and breastfeeding: Ask a clinician first. Some regions do not recommend crotamiton for young children.
- Allergy watch: Check inactive ingredients if you react to fragrance, lanolin, propylene glycol, or parabens.
Expected side effects (usually mild and short-lived):
- Temporary stinging or burning, especially on irritated skin
- Dryness or mild redness
- Contact dermatitis (less common)-itchy rash where applied
When to switch or seek alternatives:
- No improvement after a week for itch or after two weeks for scabies signs
- Severe irritation from either base
- Recurrent scabies in the household despite good technique
Alternatives to know (talk to a clinician):
- Permethrin 5% cream: Often first-line for scabies; apply neck down, single application with repeat in 7-14 days per guidance.
- Oral ivermectin: Another first-line option for many adults; dosing by weight; not for some populations.
- Sulfur ointment 5-10%: Traditional option; safe in pregnancy and infants in many settings, though messier and odorous.
- For itch alone: Cool moisturizers, short courses of low-potency topical steroids (clinician-guided), oral antihistamines for nighttime itch.
Mini‑FAQ:
- Is the lotion weaker than the cream? No. Both are typically 10% crotamiton. The base changes feel and spread, not strength.
- Which works longer? Cream tends to stay longer on dry areas; lotion can wear lighter and may need careful application to avoid rub-off.
- Can I use it on my face? Avoid eyes, lips, and mucous membranes. For facial scabies or facial itch, ask a clinician-other treatments may be safer.
- How long until itch calms? Some relief may be felt within hours. Scabies itch can persist 2-4 weeks after mites are cleared (post-scabetic itch).
- Can kids use crotamiton? Policies vary. In the U.S., it’s not widely recommended in children for scabies; always ask a pediatric clinician.
- Pregnancy or breastfeeding? Discuss with a clinician before use. Safer alternatives may be preferred for scabies.
- Can I combine with permethrin? Don’t layer them together. Use one regimen at a time. Some clinicians use separate products on different days for post-treatment itch-get tailored advice.
- What if it burns? Wash off with mild soap and cool water. Try the other form or a smaller amount after skin calms, or stop and seek advice.
Troubleshooting by scenario:
- I keep missing spots on my back: Use lotion and a long-handled applicator, or get a helper. Mark areas done with a skin-safe cosmetic pencil.
- Residue ruins my clothes: Switch to lotion, apply a thinner layer, and give it 10-15 minutes to absorb before dressing.
- Itch won’t stop after treatment: It can lag. Use bland moisturizers, cool compresses, and ask about short-term topical steroids. Recheck for reinfestation if new burrows or papules appear.
- Family keeps passing it around: Treat all close contacts at the same time and wash or isolate fabrics. Repeat treatment if your clinician advises.
- Red, bumpy rash after use: Could be contact dermatitis. Stop, switch bases, or try an alternative therapy after clinician input.
Credibility note (sources by name): This guidance aligns with FDA labeling for Eurax (crotamiton 10%), CDC Scabies Treatment materials (2024), WHO Scabies Guidelines (2023), and the British National Formulary (2025). Local labels may vary-follow your packaging and clinician’s directions.
Next steps:
- Pick your form: Cream for dry patches/overnight; lotion for large or hairy areas/daytime.
- Plan your application window: Block off time to apply thoroughly and avoid washing off early.
- Prep your space: Set out clean clothes and bag up laundry before you start.
- If treating scabies, line up household treatment and laundering on the same day.
- Book a quick check-in if you’re pregnant, treating a child, or have chronic skin disease.
If you remember nothing else: match the base to your skin and task, apply methodically, and don’t hesitate to switch forms if your skin says so.
Craig Ballantyne
September 20, 2025 AT 04:49Crotamiton's efficacy is heavily dependent on application technique, not just formulation. The CDC's 2024 guidance still positions permethrin as first-line for a reason-crotamiton has variable penetration kinetics. Lotion's lower viscosity aids in dermal diffusion across hairy surfaces, but cream's occlusive nature enhances bioavailability in xerotic zones. If you're treating scabies, prioritize complete coverage over comfort. Missed interdigital or subungual areas = treatment failure. Also, avoid combining with emollients containing propylene glycol-synergistic irritation risk.
Source: FDA Eurax labeling, 2023 revision.
Victor T. Johnson
September 22, 2025 AT 01:48Nicholas Swiontek
September 22, 2025 AT 18:43Love this breakdown! Just wanted to add that if you're using lotion for scabies, apply it in a cool room-heat makes it evaporate too fast and you end up missing spots. I used it on my back last time and had my partner help with a sponge applicator. Also, if you're sensitive to fragrances, check the label-some generic brands use lanolin or parabens that can flare eczema. Stick to the plain versions if you can.
And yes, the 24-hour repeat is non-negotiable. I skipped it once and regretted it for weeks.
Robert Asel
September 24, 2025 AT 06:23It is patently incorrect to suggest that crotamiton is a viable alternative to permethrin or ivermectin in the context of scabies eradication. The pharmacokinetic profile of crotamiton demonstrates significantly lower mite-killing efficacy, with cure rates hovering near 50% in controlled trials, versus 90%+ for permethrin. Furthermore, the British National Formulary explicitly classifies crotamiton as a second-line agent. To recommend it as a first-choice formulation is not merely misleading-it is clinically irresponsible.
Additionally, the notion that 'both contain the same drug' implies equivalence of therapeutic outcome, which is a fundamental misunderstanding of pharmaceutical formulation science. The vehicle dictates bioavailability, residence time, and ultimately, clinical utility.
Patients must be guided by evidence, not convenience.
Shannon Wright
September 25, 2025 AT 02:36I've treated over 30 scabies cases in my dermatology practice, and I can tell you-formulation matters less than application consistency. I always tell patients: if you can't see where you've applied it, you haven't applied enough. That's why I recommend lotion for the torso and back, especially for men with chest hair-it spreads like water and doesn't leave a greasy film. But for the hands, feet, and under the nails? Cream. It clings. It stays. It doesn't smear off when you scratch (and you will scratch, even if you don't mean to).
Also, please don't wash your hands right after applying. Wait at least 10 minutes. And if you're treating a child, even if the label says 'not for under 12,' ask your pediatrician. Sometimes, the risk of untreated scabies outweighs the theoretical risk of off-label use. We've used crotamiton cream on toddlers with eczema when permethrin caused burning. It worked. With supervision.
And yes, wash everything. Everything. Even the pillowcases you used the night before treatment. Scabies mites can survive up to 72 hours off the host. Don't be the person who treats themselves and then reinfests the whole family because you forgot the couch cushion.
vanessa parapar
September 25, 2025 AT 14:53Ben Wood
September 25, 2025 AT 18:06Sakthi s
September 27, 2025 AT 15:35Abhi Yadav
September 28, 2025 AT 01:32Victor T. Johnson
September 29, 2025 AT 13:32